Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 4948598..4949819 Replicon chromosome
Accession NZ_CP110350
Organism Pseudomonas aeruginosa strain PALA44

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag PALA44_RS23120 Protein ID WP_003110488.1
Coordinates 4949241..4949819 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA44_RS23115 Protein ID WP_003117666.1
Coordinates 4948598..4949152 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA44_RS23090 (PALA44_04553) 4944170..4944721 + 552 WP_003132721.1 XRE family transcriptional regulator -
PALA44_RS23095 (PALA44_04554) 4944718..4945116 - 399 WP_033990114.1 NADH-quinone oxidoreductase subunit A -
PALA44_RS23100 (PALA44_04555) 4945129..4945452 - 324 WP_003102734.1 multidrug efflux SMR transporter -
PALA44_RS23105 (PALA44_04556) 4945783..4946244 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PALA44_RS23110 (PALA44_04557) 4946249..4948444 + 2196 WP_023875495.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PALA44_RS23115 (PALA44_04558) 4948598..4949152 + 555 WP_003117666.1 helix-turn-helix transcriptional regulator Antitoxin
PALA44_RS23120 (PALA44_04559) 4949241..4949819 + 579 WP_003110488.1 HD domain-containing protein Toxin
PALA44_RS23125 (PALA44_04560) 4949929..4951116 - 1188 WP_003139884.1 HlyD family efflux transporter periplasmic adaptor subunit -
PALA44_RS23130 (PALA44_04561) 4951106..4953277 - 2172 WP_003088105.1 type I secretion system permease/ATPase -
PALA44_RS23135 (PALA44_04562) 4953267..4954544 - 1278 WP_003088104.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-66)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T263675 WP_003110488.1 NZ_CP110350:4949241-4949819 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.67 Da        Isoelectric Point: 8.5356

>AT263675 WP_003117666.1 NZ_CP110350:4948598-4949152 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADKALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References