263673

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2868053..2869748 Replicon chromosome
Accession NZ_CP110350
Organism Pseudomonas aeruginosa strain PALA44

Toxin (Protein)


Gene name doc Uniprot ID Q9HYA0
Locus tag PALA44_RS13430 Protein ID WP_003112901.1
Coordinates 2868053..2868922 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag PALA44_RS13435 Protein ID WP_003112902.1
Coordinates 2868915..2869748 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA44_RS13405 (PALA44_02653) 2864061..2864912 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
PALA44_RS13410 (PALA44_02654) 2864953..2865960 + 1008 WP_023097315.1 ABC transporter substrate-binding protein -
PALA44_RS13415 (PALA44_02655) 2865957..2866733 + 777 WP_003112898.1 ABC transporter permease -
PALA44_RS13420 (PALA44_02656) 2866739..2867500 + 762 WP_003112899.1 SDR family oxidoreductase -
PALA44_RS13425 (PALA44_02657) 2867514..2868044 + 531 WP_003112900.1 cupin domain-containing protein -
PALA44_RS13430 (PALA44_02658) 2868053..2868922 + 870 WP_003112901.1 alpha/beta hydrolase Toxin
PALA44_RS13435 (PALA44_02659) 2868915..2869748 + 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
PALA44_RS13440 (PALA44_02660) 2869735..2870532 + 798 WP_269973074.1 SDR family oxidoreductase -
PALA44_RS13445 (PALA44_02661) 2870525..2872207 + 1683 WP_003130114.1 thiamine pyrophosphate-binding protein -
PALA44_RS13450 (PALA44_02662) 2872218..2873021 + 804 WP_003130116.1 aspartate dehydrogenase -
PALA44_RS13455 (PALA44_02663) 2873033..2874517 + 1485 WP_023102925.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30403.60 Da        Isoelectric Point: 6.5894

>T263673 WP_003112901.1 NZ_CP110350:2868053-2868922 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT263673 WP_003112902.1 NZ_CP110350:2868915-2869748 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9HYA0

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References