263672

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1251556..1252061 Replicon chromosome
Accession NZ_CP110350
Organism Pseudomonas aeruginosa strain PALA44

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PALA44_RS05775 Protein ID WP_003083773.1
Coordinates 1251556..1251837 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PALA44_RS05780 Protein ID WP_003083775.1
Coordinates 1251834..1252061 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA44_RS05750 (PALA44_01136) 1246807..1248156 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
PALA44_RS05755 (PALA44_01137) 1248205..1248891 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PALA44_RS05760 (PALA44_01138) 1248992..1249726 + 735 WP_003110658.1 GntR family transcriptional regulator -
PALA44_RS05765 (PALA44_01139) 1249906..1250316 + 411 WP_003110659.1 aegerolysin family protein -
PALA44_RS05770 (PALA44_01140) 1250348..1251256 - 909 WP_003083769.1 LysR family transcriptional regulator -
PALA44_RS05775 (PALA44_01141) 1251556..1251837 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PALA44_RS05780 (PALA44_01142) 1251834..1252061 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PALA44_RS05785 (PALA44_01143) 1252237..1252857 - 621 WP_003101226.1 hypothetical protein -
PALA44_RS05790 (PALA44_01144) 1252958..1253458 + 501 WP_003162763.1 LEA type 2 family protein -
PALA44_RS05795 (PALA44_01145) 1253531..1253872 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PALA44_RS05800 (PALA44_01146) 1253954..1255381 - 1428 WP_003083784.1 GABA permease -
PALA44_RS05805 (PALA44_01147) 1255550..1257043 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T263672 WP_003083773.1 NZ_CP110350:c1251837-1251556 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT263672 WP_003083775.1 NZ_CP110350:c1252061-1251834 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References