Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 5005659..5006917 Replicon chromosome
Accession NZ_CP110349
Organism Pseudomonas aeruginosa strain PALA40

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag PALA40_RS23615 Protein ID WP_003112528.1
Coordinates 5005659..5006414 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA40_RS23620 Protein ID WP_003086329.1
Coordinates 5006549..5006917 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA40_RS23605 (PALA40_04653) 5000832..5003375 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
PALA40_RS23610 (PALA40_04654) 5003530..5004891 - 1362 WP_073647918.1 DNA recombination protein RmuC -
PALA40_RS23615 (PALA40_04655) 5005659..5006414 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
PALA40_RS23620 (PALA40_04656) 5006549..5006917 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA40_RS23625 (PALA40_04657) 5006990..5008276 - 1287 WP_023083139.1 FAD-binding oxidoreductase -
PALA40_RS23630 (PALA40_04658) 5008332..5009921 - 1590 WP_003125055.1 aldehyde dehydrogenase family protein -
PALA40_RS23635 (PALA40_04659) 5010000..5010476 + 477 WP_003112531.1 hypothetical protein -
PALA40_RS23640 5010479..5010754 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T263668 WP_003112528.1 NZ_CP110349:c5006414-5005659 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT263668 WP_003086329.1 NZ_CP110349:c5006917-5006549 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References