263666

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 3000028..3001070 Replicon chromosome
Accession NZ_CP110349
Organism Pseudomonas aeruginosa strain PALA40

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag PALA40_RS14385 Protein ID WP_003153636.1
Coordinates 3000495..3001070 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag PALA40_RS14380 Protein ID WP_003050245.1
Coordinates 3000028..3000498 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA40_RS14345 (PALA40_02843) 2995420..2996838 - 1419 WP_006226029.1 TIGR03752 family integrating conjugative element protein -
PALA40_RS14350 (PALA40_02844) 2996828..2997739 - 912 WP_006226028.1 TIGR03749 family integrating conjugative element protein -
PALA40_RS14355 (PALA40_02845) 2997736..2998428 - 693 WP_003090182.1 TIGR03746 family integrating conjugative element protein -
PALA40_RS14360 (PALA40_02846) 2998425..2998823 - 399 WP_003050133.1 TIGR03750 family conjugal transfer protein -
PALA40_RS14365 (PALA40_02847) 2998835..2999194 - 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
PALA40_RS14370 (PALA40_02848) 2999211..2999444 - 234 WP_006226027.1 TIGR03758 family integrating conjugative element protein -
PALA40_RS14375 (PALA40_02849) 2999441..2999824 - 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
PALA40_RS14380 (PALA40_02850) 3000028..3000498 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
PALA40_RS14385 (PALA40_02851) 3000495..3001070 + 576 WP_003153636.1 PIN domain-containing protein Toxin
PALA40_RS14390 (PALA40_02852) 3001088..3002002 + 915 WP_016852809.1 AAA family ATPase -
PALA40_RS14395 (PALA40_02853) 3001999..3002469 + 471 WP_003090160.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
PALA40_RS14400 (PALA40_02854) 3002466..3002966 + 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
PALA40_RS14405 (PALA40_02855) 3002966..3003868 + 903 WP_003090158.1 CBASS oligonucleotide cyclase -
PALA40_RS14410 (PALA40_02856) 3003907..3004632 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2925453..3047186 121733


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T263666 WP_003153636.1 NZ_CP110349:3000495-3001070 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT263666 WP_003050245.1 NZ_CP110349:3000028-3000498 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References