Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1786413..1788108 Replicon chromosome
Accession NZ_CP110349
Organism Pseudomonas aeruginosa strain PALA40

Toxin (Protein)


Gene name doc Uniprot ID Q9HYA0
Locus tag PALA40_RS08390 Protein ID WP_003112901.1
Coordinates 1786413..1787282 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag PALA40_RS08395 Protein ID WP_003112902.1
Coordinates 1787275..1788108 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA40_RS08365 (PALA40_01658) 1782421..1783272 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
PALA40_RS08370 (PALA40_01659) 1783313..1784320 + 1008 WP_023083382.1 ABC transporter substrate-binding protein -
PALA40_RS08375 (PALA40_01660) 1784317..1785093 + 777 WP_003112898.1 ABC transporter permease -
PALA40_RS08380 (PALA40_01661) 1785099..1785860 + 762 WP_023083383.1 SDR family oxidoreductase -
PALA40_RS08385 (PALA40_01662) 1785874..1786404 + 531 WP_003112900.1 cupin domain-containing protein -
PALA40_RS08390 (PALA40_01663) 1786413..1787282 + 870 WP_003112901.1 alpha/beta hydrolase Toxin
PALA40_RS08395 (PALA40_01664) 1787275..1788108 + 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
PALA40_RS08400 (PALA40_01665) 1788095..1788892 + 798 WP_003112903.1 SDR family oxidoreductase -
PALA40_RS08405 (PALA40_01666) 1788885..1790567 + 1683 WP_003130114.1 thiamine pyrophosphate-binding protein -
PALA40_RS08410 (PALA40_01667) 1790578..1791381 + 804 WP_003130116.1 aspartate dehydrogenase -
PALA40_RS08415 (PALA40_01668) 1791393..1792877 + 1485 WP_003453562.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30403.60 Da        Isoelectric Point: 6.5894

>T263664 WP_003112901.1 NZ_CP110349:1786413-1787282 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT263664 WP_003112902.1 NZ_CP110349:1787275-1788108 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9HYA0

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References