Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3852223..3853444 Replicon chromosome
Accession NZ_CP110348
Organism Pseudomonas aeruginosa strain PALA36

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag PALA36_RS18070 Protein ID WP_003110488.1
Coordinates 3852866..3853444 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA36_RS18065 Protein ID WP_003117666.1
Coordinates 3852223..3852777 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA36_RS18040 (PALA36_03553) 3847795..3848346 + 552 WP_003132721.1 XRE family transcriptional regulator -
PALA36_RS18045 (PALA36_03554) 3848343..3848741 - 399 WP_033990114.1 NADH-quinone oxidoreductase subunit A -
PALA36_RS18050 (PALA36_03555) 3848754..3849077 - 324 WP_003102734.1 multidrug efflux SMR transporter -
PALA36_RS18055 (PALA36_03556) 3849408..3849869 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PALA36_RS18060 (PALA36_03557) 3849874..3852069 + 2196 WP_023875495.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PALA36_RS18065 (PALA36_03558) 3852223..3852777 + 555 WP_003117666.1 helix-turn-helix transcriptional regulator Antitoxin
PALA36_RS18070 (PALA36_03559) 3852866..3853444 + 579 WP_003110488.1 HD domain-containing protein Toxin
PALA36_RS18075 (PALA36_03560) 3853554..3854741 - 1188 WP_003139884.1 HlyD family efflux transporter periplasmic adaptor subunit -
PALA36_RS18080 (PALA36_03561) 3854731..3856902 - 2172 WP_003088105.1 type I secretion system permease/ATPase -
PALA36_RS18085 (PALA36_03562) 3856892..3858169 - 1278 WP_003088104.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-66)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T263660 WP_003110488.1 NZ_CP110348:3852866-3853444 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.67 Da        Isoelectric Point: 8.5356

>AT263660 WP_003117666.1 NZ_CP110348:3852223-3852777 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADKALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References