Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 2043399..2044903 Replicon chromosome
Accession NZ_CP110348
Organism Pseudomonas aeruginosa strain PALA36

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag PALA36_RS09645 Protein ID WP_003119682.1
Coordinates 2043399..2043986 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A9E8LAI1
Locus tag PALA36_RS09650 Protein ID WP_003117606.1
Coordinates 2044049..2044903 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA36_RS09640 (PALA36_01905) 2039654..2043133 - 3480 WP_033938798.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
PALA36_RS09645 (PALA36_01906) 2043399..2043986 + 588 WP_003119682.1 GNAT family protein Toxin
PALA36_RS09650 (PALA36_01907) 2044049..2044903 + 855 WP_003117606.1 AraC family transcriptional regulator Antitoxin
PALA36_RS09655 (PALA36_01908) 2045000..2047165 + 2166 WP_033989266.1 TonB-dependent receptor family protein -
PALA36_RS09660 (PALA36_01909) 2047340..2049214 + 1875 WP_003117607.1 MFS transporter -
PALA36_RS09665 (PALA36_01910) 2049275..2049484 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T263659 WP_003119682.1 NZ_CP110348:2043399-2043986 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31863.14 Da        Isoelectric Point: 7.5295

>AT263659 WP_003117606.1 NZ_CP110348:2044049-2044903 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure

References