Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1771678..1773373 Replicon chromosome
Accession NZ_CP110348
Organism Pseudomonas aeruginosa strain PALA36

Toxin (Protein)


Gene name doc Uniprot ID Q9HYA0
Locus tag PALA36_RS08380 Protein ID WP_003112901.1
Coordinates 1771678..1772547 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag PALA36_RS08385 Protein ID WP_003112902.1
Coordinates 1772540..1773373 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA36_RS08355 (PALA36_01653) 1767686..1768537 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
PALA36_RS08360 (PALA36_01654) 1768578..1769585 + 1008 WP_023097315.1 ABC transporter substrate-binding protein -
PALA36_RS08365 (PALA36_01655) 1769582..1770358 + 777 WP_003112898.1 ABC transporter permease -
PALA36_RS08370 (PALA36_01656) 1770364..1771125 + 762 WP_003112899.1 SDR family oxidoreductase -
PALA36_RS08375 (PALA36_01657) 1771139..1771669 + 531 WP_003112900.1 cupin domain-containing protein -
PALA36_RS08380 (PALA36_01658) 1771678..1772547 + 870 WP_003112901.1 alpha/beta hydrolase Toxin
PALA36_RS08385 (PALA36_01659) 1772540..1773373 + 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
PALA36_RS08390 (PALA36_01660) 1773360..1774157 + 798 WP_269973074.1 SDR family oxidoreductase -
PALA36_RS08395 (PALA36_01661) 1774150..1775832 + 1683 WP_003130114.1 thiamine pyrophosphate-binding protein -
PALA36_RS08400 (PALA36_01662) 1775843..1776646 + 804 WP_003130116.1 aspartate dehydrogenase -
PALA36_RS08405 (PALA36_01663) 1776658..1778142 + 1485 WP_023102925.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30403.60 Da        Isoelectric Point: 6.5894

>T263658 WP_003112901.1 NZ_CP110348:1771678-1772547 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT263658 WP_003112902.1 NZ_CP110348:1772540-1773373 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9HYA0

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References