Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 155181..155686 Replicon chromosome
Accession NZ_CP110348
Organism Pseudomonas aeruginosa strain PALA36

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PALA36_RS00725 Protein ID WP_003083773.1
Coordinates 155181..155462 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PALA36_RS00730 Protein ID WP_003083775.1
Coordinates 155459..155686 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA36_RS00700 (PALA36_00137) 150432..151781 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
PALA36_RS00705 (PALA36_00138) 151830..152516 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PALA36_RS00710 (PALA36_00139) 152617..153351 + 735 WP_003110658.1 GntR family transcriptional regulator -
PALA36_RS00715 (PALA36_00140) 153531..153941 + 411 WP_003110659.1 aegerolysin family protein -
PALA36_RS00720 (PALA36_00141) 153973..154881 - 909 WP_003083769.1 LysR family transcriptional regulator -
PALA36_RS00725 (PALA36_00142) 155181..155462 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PALA36_RS00730 (PALA36_00143) 155459..155686 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PALA36_RS00735 (PALA36_00144) 155862..156482 - 621 WP_003101226.1 hypothetical protein -
PALA36_RS00740 (PALA36_00145) 156583..157083 + 501 WP_003162763.1 LEA type 2 family protein -
PALA36_RS00745 (PALA36_00146) 157156..157497 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PALA36_RS00750 (PALA36_00147) 157579..159006 - 1428 WP_003083784.1 GABA permease -
PALA36_RS00755 (PALA36_00148) 159175..160668 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T263657 WP_003083773.1 NZ_CP110348:c155462-155181 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT263657 WP_003083775.1 NZ_CP110348:c155686-155459 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References