263655

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4381165..4382422 Replicon chromosome
Accession NZ_CP110347
Organism Pseudomonas aeruginosa strain PALA52

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PALA52_RS20185 Protein ID WP_058140803.1
Coordinates 4381165..4381920 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA52_RS20190 Protein ID WP_003086329.1
Coordinates 4382054..4382422 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA52_RS20175 (PALA52_04012) 4376342..4378885 + 2544 WP_124181096.1 acyl-homoserine-lactone acylase QuiP -
PALA52_RS20180 (PALA52_04013) 4379032..4380393 - 1362 WP_079752925.1 DNA recombination protein RmuC -
PALA52_RS20185 (PALA52_04014) 4381165..4381920 - 756 WP_058140803.1 RES family NAD+ phosphorylase Toxin
PALA52_RS20190 (PALA52_04015) 4382054..4382422 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA52_RS20195 (PALA52_04016) 4382495..4383781 - 1287 WP_003112529.1 FAD-binding oxidoreductase -
PALA52_RS20200 (PALA52_04017) 4383837..4385426 - 1590 WP_263957058.1 aldehyde dehydrogenase family protein -
PALA52_RS20205 (PALA52_04018) 4385503..4385979 + 477 WP_024915076.1 elongation factor GreAB -
PALA52_RS20210 (PALA52_04019) 4385982..4386257 - 276 WP_049942684.1 zinc ribbon domain-containing protein -
PALA52_RS20215 (PALA52_04020) 4386391..4386769 - 379 Protein_4002 OprD family outer membrane porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28341.52 Da        Isoelectric Point: 7.7279

>T263655 WP_058140803.1 NZ_CP110347:c4381920-4381165 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLHVPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPVAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPYPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT263655 WP_003086329.1 NZ_CP110347:c4382422-4382054 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References