Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 3480724..3481945 | Replicon | chromosome |
| Accession | NZ_CP110347 | ||
| Organism | Pseudomonas aeruginosa strain PALA52 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | PALA52_RS16010 | Protein ID | WP_024918215.1 |
| Coordinates | 3481367..3481945 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | PALA52_RS16005 | Protein ID | WP_024918216.1 |
| Coordinates | 3480724..3481278 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PALA52_RS15980 (PALA52_03172) | 3476293..3476844 | + | 552 | WP_221921664.1 | XRE family transcriptional regulator | - |
| PALA52_RS15985 (PALA52_03173) | 3476841..3477239 | - | 399 | WP_024918219.1 | NADH-quinone oxidoreductase subunit A | - |
| PALA52_RS15990 (PALA52_03174) | 3477252..3477575 | - | 324 | WP_023106612.1 | multidrug efflux SMR transporter | - |
| PALA52_RS15995 (PALA52_03175) | 3477906..3478367 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| PALA52_RS16000 (PALA52_03176) | 3478372..3480567 | + | 2196 | WP_058140421.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| PALA52_RS16005 (PALA52_03177) | 3480724..3481278 | + | 555 | WP_024918216.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| PALA52_RS16010 (PALA52_03178) | 3481367..3481945 | + | 579 | WP_024918215.1 | HD domain-containing protein | Toxin |
| PALA52_RS16015 (PALA52_03179) | 3482072..3483154 | + | 1083 | WP_263957218.1 | FAD-binding oxidoreductase | - |
| PALA52_RS16020 (PALA52_03180) | 3483309..3484496 | - | 1188 | WP_263957219.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| PALA52_RS16025 (PALA52_03181) | 3484486..3486657 | - | 2172 | WP_270124570.1 | type I secretion system permease/ATPase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21913.70 Da Isoelectric Point: 5.0263
>T263654 WP_024918215.1 NZ_CP110347:3481367-3481945 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRERLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLEAQRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRERLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLEAQRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20458.62 Da Isoelectric Point: 8.5375
>AT263654 WP_024918216.1 NZ_CP110347:3480724-3481278 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLLEERARLERLLGARLESAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGDLLGRSLWPYCSEEILRQETTLEDLGWRELLAPPTLEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLLEERARLERLLGARLESAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGDLLGRSLWPYCSEEILRQETTLEDLGWRELLAPPTLEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|