Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 141837..142342 Replicon chromosome
Accession NZ_CP110347
Organism Pseudomonas aeruginosa strain PALA52

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag PALA52_RS00655 Protein ID WP_263957364.1
Coordinates 141837..142118 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PALA52_RS00660 Protein ID WP_003083775.1
Coordinates 142115..142342 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA52_RS00630 (PALA52_00121) 137083..138432 + 1350 WP_079752987.1 C4-dicarboxylate transporter DctA -
PALA52_RS00635 (PALA52_00122) 138481..139167 + 687 WP_024916687.1 FadR/GntR family transcriptional regulator -
PALA52_RS00640 (PALA52_00123) 139269..140003 + 735 WP_024916686.1 GntR family transcriptional regulator -
PALA52_RS00645 (PALA52_00124) 140183..140593 + 411 WP_024916685.1 aegerolysin family protein -
PALA52_RS00650 (PALA52_00125) 140628..141536 - 909 WP_263957365.1 LysR family transcriptional regulator -
PALA52_RS00655 (PALA52_00126) 141837..142118 - 282 WP_263957364.1 type II toxin-antitoxin system toxin ParE Toxin
PALA52_RS00660 (PALA52_00127) 142115..142342 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PALA52_RS00665 (PALA52_00128) 142518..143138 - 621 WP_263957363.1 hypothetical protein -
PALA52_RS00670 (PALA52_00129) 143239..143739 + 501 WP_024916682.1 LEA type 2 family protein -
PALA52_RS00675 (PALA52_00130) 143812..144153 + 342 WP_024916681.1 zinc ribbon domain-containing protein YjdM -
PALA52_RS00680 (PALA52_00131) 144273..145700 - 1428 WP_270125000.1 GABA permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10445.21 Da        Isoelectric Point: 9.6558

>T263652 WP_263957364.1 NZ_CP110347:c142118-141837 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQEVANQGAGRPSEVPGVRTLALERWPFSAPFRVKGKE
IQILRIDRVEIIP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT263652 WP_003083775.1 NZ_CP110347:c142342-142115 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References