Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4682391..4683649 Replicon chromosome
Accession NZ_CP110346
Organism Pseudomonas aeruginosa strain PALA35

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag PALA35_RS21795 Protein ID WP_003086331.1
Coordinates 4682391..4683146 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA35_RS21800 Protein ID WP_003086329.1
Coordinates 4683281..4683649 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA35_RS21785 (PALA35_04314) 4677562..4680105 + 2544 WP_269974394.1 acyl-homoserine-lactone acylase QuiP -
PALA35_RS21790 (PALA35_04315) 4680260..4681621 - 1362 WP_003081943.1 DNA recombination protein RmuC -
PALA35_RS21795 (PALA35_04316) 4682391..4683146 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
PALA35_RS21800 (PALA35_04317) 4683281..4683649 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA35_RS21805 (PALA35_04318) 4683722..4685008 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
PALA35_RS21810 (PALA35_04319) 4685064..4686653 - 1590 WP_269974395.1 aldehyde dehydrogenase family protein -
PALA35_RS21815 (PALA35_04320) 4686731..4687207 + 477 WP_009877993.1 elongation factor GreAB -
PALA35_RS21820 (PALA35_04321) 4687210..4687485 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T263649 WP_003086331.1 NZ_CP110346:c4683146-4682391 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT263649 WP_003086329.1 NZ_CP110346:c4683649-4683281 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References