Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 3728922..3730143 | Replicon | chromosome |
| Accession | NZ_CP110346 | ||
| Organism | Pseudomonas aeruginosa strain PALA35 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | PALA35_RS17325 | Protein ID | WP_003118970.1 |
| Coordinates | 3729565..3730143 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | PALA35_RS17320 | Protein ID | WP_269974255.1 |
| Coordinates | 3728922..3729476 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PALA35_RS17295 (PALA35_03423) | 3724488..3725039 | + | 552 | WP_058201053.1 | XRE family transcriptional regulator | - |
| PALA35_RS17300 (PALA35_03424) | 3725036..3725434 | - | 399 | WP_023436383.1 | NADH-quinone oxidoreductase subunit A | - |
| PALA35_RS17305 (PALA35_03425) | 3725447..3725770 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| PALA35_RS17310 (PALA35_03426) | 3726101..3726562 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| PALA35_RS17315 (PALA35_03427) | 3726567..3728762 | + | 2196 | WP_269974254.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| PALA35_RS17320 (PALA35_03428) | 3728922..3729476 | + | 555 | WP_269974255.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| PALA35_RS17325 (PALA35_03429) | 3729565..3730143 | + | 579 | WP_003118970.1 | HD domain-containing protein | Toxin |
| PALA35_RS17330 (PALA35_03430) | 3730252..3731439 | - | 1188 | WP_003132729.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| PALA35_RS17335 (PALA35_03431) | 3731429..3733600 | - | 2172 | WP_003088105.1 | type I secretion system permease/ATPase | - |
| PALA35_RS17340 (PALA35_03432) | 3733590..3734867 | - | 1278 | WP_269974256.1 | TolC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21899.72 Da Isoelectric Point: 5.3655
>T263648 WP_003118970.1 NZ_CP110346:3729565-3730143 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20500.65 Da Isoelectric Point: 8.1590
>AT263648 WP_269974255.1 NZ_CP110346:3728922-3729476 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLESAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFTSGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLESAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFTSGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|