Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1684711..1686406 Replicon chromosome
Accession NZ_CP110346
Organism Pseudomonas aeruginosa strain PALA35

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag PALA35_RS07995 Protein ID WP_023097317.1
Coordinates 1684711..1685580 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A7M3AXM3
Locus tag PALA35_RS08000 Protein ID WP_023108658.1
Coordinates 1685573..1686406 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA35_RS07970 (PALA35_01588) 1680719..1681570 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
PALA35_RS07975 (PALA35_01589) 1681611..1682618 + 1008 WP_023106073.1 ABC transporter substrate-binding protein -
PALA35_RS07980 (PALA35_01590) 1682615..1683391 + 777 WP_003112898.1 ABC transporter permease -
PALA35_RS07985 (PALA35_01591) 1683397..1684158 + 762 WP_023106074.1 SDR family oxidoreductase -
PALA35_RS07990 (PALA35_01592) 1684172..1684702 + 531 WP_003112900.1 cupin domain-containing protein -
PALA35_RS07995 (PALA35_01593) 1684711..1685580 + 870 WP_023097317.1 alpha/beta hydrolase Toxin
PALA35_RS08000 (PALA35_01594) 1685573..1686406 + 834 WP_023108658.1 IclR family transcriptional regulator Antitoxin
PALA35_RS08005 (PALA35_01595) 1686393..1687190 + 798 WP_022579702.1 SDR family oxidoreductase -
PALA35_RS08010 (PALA35_01596) 1687183..1688865 + 1683 WP_003130114.1 thiamine pyrophosphate-binding protein -
PALA35_RS08015 (PALA35_01597) 1688876..1689679 + 804 WP_003453564.1 aspartate dehydrogenase -
PALA35_RS08020 (PALA35_01598) 1689691..1691175 + 1485 WP_033942409.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30405.65 Da        Isoelectric Point: 6.5921

>T263646 WP_023097317.1 NZ_CP110346:1684711-1685580 [Pseudomonas aeruginosa]
MNMAQTHIPAPSLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSSP
LPPAWPKACDYAARLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERLGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSPIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30819.22 Da        Isoelectric Point: 6.1414

>AT263646 WP_023108658.1 NZ_CP110346:1685573-1686406 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPARIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7M3AXM3

References