Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 141772..142277 Replicon chromosome
Accession NZ_CP110346
Organism Pseudomonas aeruginosa strain PALA35

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PALA35_RS00655 Protein ID WP_003083773.1
Coordinates 141772..142053 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0H2ZJU8
Locus tag PALA35_RS00660 Protein ID WP_003137009.1
Coordinates 142050..142277 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA35_RS00630 (PALA35_00126) 137023..138372 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
PALA35_RS00635 (PALA35_00127) 138421..139101 + 681 WP_043084877.1 FadR/GntR family transcriptional regulator -
PALA35_RS00640 (PALA35_00128) 139208..139942 + 735 WP_023107524.1 GntR family transcriptional regulator -
PALA35_RS00645 (PALA35_00129) 140122..140532 + 411 WP_003110659.1 aegerolysin family protein -
PALA35_RS00650 (PALA35_00130) 140564..141472 - 909 WP_269974638.1 LysR family transcriptional regulator -
PALA35_RS00655 (PALA35_00131) 141772..142053 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PALA35_RS00660 (PALA35_00132) 142050..142277 - 228 WP_003137009.1 CopG family ribbon-helix-helix protein Antitoxin
PALA35_RS00665 (PALA35_00133) 142453..143073 - 621 WP_269974639.1 hypothetical protein -
PALA35_RS00670 (PALA35_00134) 143174..143674 + 501 WP_003101228.1 LEA type 2 family protein -
PALA35_RS00675 (PALA35_00135) 143747..144088 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PALA35_RS00680 (PALA35_00136) 144173..145600 - 1428 WP_023092260.1 GABA permease -
PALA35_RS00685 (PALA35_00137) 145769..147262 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T263643 WP_003083773.1 NZ_CP110346:c142053-141772 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8526.56 Da        Isoelectric Point: 5.5740

>AT263643 WP_003137009.1 NZ_CP110346:c142277-142050 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHAEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A0H2ZJU8

References