Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4791216..4792474 Replicon chromosome
Accession NZ_CP110345
Organism Pseudomonas aeruginosa strain PALA30

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag PALA30_RS22560 Protein ID WP_003086331.1
Coordinates 4791216..4791971 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA30_RS22565 Protein ID WP_003086329.1
Coordinates 4792106..4792474 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA30_RS22550 (PALA30_04445) 4786384..4788927 + 2544 WP_058176229.1 acyl-homoserine-lactone acylase QuiP -
PALA30_RS22555 (PALA30_04446) 4789082..4790443 - 1362 WP_003134034.1 DNA recombination protein RmuC -
PALA30_RS22560 (PALA30_04447) 4791216..4791971 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
PALA30_RS22565 (PALA30_04448) 4792106..4792474 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA30_RS22570 (PALA30_04449) 4792547..4793833 - 1287 WP_003134035.1 FAD-binding oxidoreductase -
PALA30_RS22575 (PALA30_04450) 4793889..4795478 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
PALA30_RS22580 (PALA30_04451) 4795557..4796033 + 477 WP_003116995.1 hypothetical protein -
PALA30_RS22585 4796036..4796311 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T263640 WP_003086331.1 NZ_CP110345:c4791971-4791216 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT263640 WP_003086329.1 NZ_CP110345:c4792474-4792106 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References