Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3857777..3858998 Replicon chromosome
Accession NZ_CP110345
Organism Pseudomonas aeruginosa strain PALA30

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag PALA30_RS18120 Protein ID WP_003110488.1
Coordinates 3858420..3858998 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA30_RS18115 Protein ID WP_003088112.1
Coordinates 3857777..3858331 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA30_RS18090 (PALA30_03566) 3853345..3853896 + 552 WP_031685890.1 XRE family transcriptional regulator -
PALA30_RS18095 (PALA30_03567) 3853893..3854291 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PALA30_RS18100 (PALA30_03568) 3854304..3854627 - 324 WP_003102734.1 multidrug efflux SMR transporter -
PALA30_RS18105 (PALA30_03569) 3854958..3855419 + 462 WP_003088117.1 (2Fe-2S)-binding protein -
PALA30_RS18110 (PALA30_03570) 3855424..3857619 + 2196 WP_058176867.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PALA30_RS18115 (PALA30_03571) 3857777..3858331 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PALA30_RS18120 (PALA30_03572) 3858420..3858998 + 579 WP_003110488.1 HD domain-containing protein Toxin
PALA30_RS18125 (PALA30_03573) 3859108..3860295 - 1188 WP_021264658.1 HlyD family efflux transporter periplasmic adaptor subunit -
PALA30_RS18130 (PALA30_03574) 3860285..3862456 - 2172 WP_058176869.1 type I secretion system permease/ATPase -
PALA30_RS18135 (PALA30_03575) 3862446..3863723 - 1278 WP_003088104.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T263639 WP_003110488.1 NZ_CP110345:3858420-3858998 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT263639 WP_003088112.1 NZ_CP110345:3857777-3858331 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References