263638

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2860956..2861998 Replicon chromosome
Accession NZ_CP110345
Organism Pseudomonas aeruginosa strain PALA30

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag PALA30_RS13750 Protein ID WP_003153636.1
Coordinates 2861423..2861998 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag PALA30_RS13745 Protein ID WP_003050245.1
Coordinates 2860956..2861426 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA30_RS13710 (PALA30_02709) 2856348..2857766 - 1419 WP_023100422.1 TIGR03752 family integrating conjugative element protein -
PALA30_RS13715 (PALA30_02710) 2857756..2858667 - 912 WP_023100423.1 TIGR03749 family integrating conjugative element protein -
PALA30_RS13720 (PALA30_02711) 2858664..2859356 - 693 WP_023100424.1 TIGR03746 family integrating conjugative element protein -
PALA30_RS13725 (PALA30_02712) 2859353..2859751 - 399 WP_003105639.1 TIGR03750 family conjugal transfer protein -
PALA30_RS13730 (PALA30_02713) 2859763..2860122 - 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
PALA30_RS13735 (PALA30_02714) 2860139..2860372 - 234 WP_003090170.1 TIGR03758 family integrating conjugative element protein -
PALA30_RS13740 (PALA30_02715) 2860369..2860752 - 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
PALA30_RS13745 (PALA30_02716) 2860956..2861426 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
PALA30_RS13750 (PALA30_02717) 2861423..2861998 + 576 WP_003153636.1 PIN domain-containing protein Toxin
PALA30_RS13755 (PALA30_02718) 2862016..2862930 + 915 WP_016852809.1 AAA family ATPase -
PALA30_RS13760 (PALA30_02719) 2862927..2863397 + 471 WP_003090160.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
PALA30_RS13765 (PALA30_02720) 2863394..2863894 + 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
PALA30_RS13770 (PALA30_02721) 2863894..2864796 + 903 WP_003090158.1 CBASS oligonucleotide cyclase -
PALA30_RS13775 (PALA30_02722) 2864835..2865560 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2775080..2910396 135316


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T263638 WP_003153636.1 NZ_CP110345:2861423-2861998 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT263638 WP_003050245.1 NZ_CP110345:2860956-2861426 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References