Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 4385084..4386304 | Replicon | chromosome |
| Accession | NZ_CP110344 | ||
| Organism | Pseudomonas aeruginosa strain PALA24 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | PALA24_RS20980 | Protein ID | WP_003118970.1 |
| Coordinates | 4385726..4386304 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | PALA24_RS20975 | Protein ID | WP_003088112.1 |
| Coordinates | 4385084..4385638 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PALA24_RS20950 (PALA24_04184) | 4380652..4381203 | + | 552 | WP_003102727.1 | XRE family transcriptional regulator | - |
| PALA24_RS20955 (PALA24_04185) | 4381200..4381598 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
| PALA24_RS20960 (PALA24_04186) | 4381611..4381934 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| PALA24_RS20965 (PALA24_04187) | 4382265..4382726 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| PALA24_RS20970 (PALA24_04188) | 4382731..4384926 | + | 2196 | WP_003118969.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| PALA24_RS20975 (PALA24_04189) | 4385084..4385638 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| PALA24_RS20980 (PALA24_04190) | 4385726..4386304 | + | 579 | WP_003118970.1 | HD domain-containing protein | Toxin |
| PALA24_RS20985 (PALA24_04191) | 4386412..4387599 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| PALA24_RS20990 (PALA24_04192) | 4387589..4389760 | - | 2172 | WP_003114950.1 | type I secretion system permease/ATPase | - |
| PALA24_RS20995 (PALA24_04193) | 4389750..4391027 | - | 1278 | WP_058165152.1 | TolC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21899.72 Da Isoelectric Point: 5.3655
>T263633 WP_003118970.1 NZ_CP110344:4385726-4386304 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT263633 WP_003088112.1 NZ_CP110344:4385084-4385638 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|