263632

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 3828327..3829585 Replicon chromosome
Accession NZ_CP110344
Organism Pseudomonas aeruginosa strain PALA24

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag PALA24_RS18335 Protein ID WP_003112528.1
Coordinates 3828830..3829585 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA24_RS18330 Protein ID WP_003086329.1
Coordinates 3828327..3828695 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA24_RS18310 3824490..3824765 + 276 WP_010792073.1 zinc ribbon domain-containing protein -
PALA24_RS18315 (PALA24_03650) 3824768..3825244 - 477 WP_003112531.1 hypothetical protein -
PALA24_RS18320 (PALA24_03651) 3825323..3826912 + 1590 WP_003125055.1 aldehyde dehydrogenase family protein -
PALA24_RS18325 (PALA24_03652) 3826968..3828254 + 1287 WP_003112529.1 FAD-binding oxidoreductase -
PALA24_RS18330 (PALA24_03653) 3828327..3828695 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA24_RS18335 (PALA24_03654) 3828830..3829585 + 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
PALA24_RS18340 (PALA24_03655) 3830354..3831715 + 1362 WP_003120632.1 DNA recombination protein RmuC -
PALA24_RS18345 (PALA24_03656) 3831871..3834414 - 2544 WP_003120631.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T263632 WP_003112528.1 NZ_CP110344:3828830-3829585 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT263632 WP_003086329.1 NZ_CP110344:3828327-3828695 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References