263631

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 3089247..3089833 Replicon chromosome
Accession NZ_CP110344
Organism Pseudomonas aeruginosa strain PALA24

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag PALA24_RS14840 Protein ID WP_003120987.1
Coordinates 3089247..3089546 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag PALA24_RS14845 Protein ID WP_003448662.1
Coordinates 3089543..3089833 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA24_RS14820 (PALA24_02949) 3084363..3084896 - 534 WP_003120993.1 type IV pilus biogenesis protein PilP -
PALA24_RS14825 (PALA24_02950) 3084886..3086211 - 1326 WP_003120992.1 type 4b pilus protein PilO2 -
PALA24_RS14830 (PALA24_02951) 3086215..3087924 - 1710 WP_010792227.1 PilN family type IVB pilus formation outer membrane protein -
PALA24_RS14835 (PALA24_02952) 3087924..3089045 - 1122 WP_003448658.1 TcpQ domain-containing protein -
PALA24_RS14840 (PALA24_02953) 3089247..3089546 + 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA24_RS14845 (PALA24_02954) 3089543..3089833 + 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
PALA24_RS14850 3089904..3090248 - 345 WP_003448665.1 hypothetical protein -
PALA24_RS14855 3090245..3090379 - 135 WP_033179080.1 hypothetical protein -
PALA24_RS14860 (PALA24_02955) 3090389..3092365 - 1977 WP_010792226.1 DEAD/DEAH box helicase -
PALA24_RS14865 (PALA24_02956) 3092362..3094251 - 1890 WP_003448700.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3029642..3118781 89139


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T263631 WP_003120987.1 NZ_CP110344:3089247-3089546 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT263631 WP_003448662.1 NZ_CP110344:3089543-3089833 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References