263627

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1856132..1857640 Replicon chromosome
Accession NZ_CP110344
Organism Pseudomonas aeruginosa strain PALA24

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag PALA24_RS08630 Protein ID WP_003119682.1
Coordinates 1856132..1856719 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A5B3ABU1
Locus tag PALA24_RS08635 Protein ID WP_003119683.1
Coordinates 1856786..1857640 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA24_RS08625 (PALA24_01715) 1852387..1855866 - 3480 WP_003119681.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
PALA24_RS08630 (PALA24_01716) 1856132..1856719 + 588 WP_003119682.1 GNAT family protein Toxin
PALA24_RS08635 (PALA24_01717) 1856786..1857640 + 855 WP_003119683.1 AraC family transcriptional regulator Antitoxin
PALA24_RS08640 (PALA24_01718) 1857737..1859902 + 2166 WP_003115567.1 TonB-dependent receptor family protein -
PALA24_RS08645 (PALA24_01719) 1860077..1861951 + 1875 WP_003117607.1 MFS transporter -
PALA24_RS08650 (PALA24_01720) 1862012..1862221 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T263627 WP_003119682.1 NZ_CP110344:1856132-1856719 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31875.19 Da        Isoelectric Point: 7.5295

>AT263627 WP_003119683.1 NZ_CP110344:1856786-1857640 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A5B3ABU1

References