263626

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 150454..150959 Replicon chromosome
Accession NZ_CP110344
Organism Pseudomonas aeruginosa strain PALA24

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PALA24_RS00685 Protein ID WP_003083773.1
Coordinates 150454..150735 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PALA24_RS00690 Protein ID WP_003083775.1
Coordinates 150732..150959 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA24_RS00660 (PALA24_00129) 145705..147054 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
PALA24_RS00665 (PALA24_00130) 147103..147789 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PALA24_RS00670 (PALA24_00131) 147890..148624 + 735 WP_003117208.1 GntR family transcriptional regulator -
PALA24_RS00675 (PALA24_00132) 148804..149214 + 411 WP_003101225.1 aegerolysin family protein -
PALA24_RS00680 (PALA24_00133) 149246..150154 - 909 WP_003083769.1 LysR family transcriptional regulator -
PALA24_RS00685 (PALA24_00134) 150454..150735 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PALA24_RS00690 (PALA24_00135) 150732..150959 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PALA24_RS00695 (PALA24_00136) 151135..151755 - 621 WP_003101226.1 hypothetical protein -
PALA24_RS00700 (PALA24_00137) 151856..152356 + 501 WP_003101228.1 LEA type 2 family protein -
PALA24_RS00705 (PALA24_00138) 152429..152770 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PALA24_RS00710 (PALA24_00139) 152852..154279 - 1428 WP_003083784.1 GABA permease -
PALA24_RS00715 (PALA24_00140) 154448..155941 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T263626 WP_003083773.1 NZ_CP110344:c150735-150454 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT263626 WP_003083775.1 NZ_CP110344:c150959-150732 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References