Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 4187096..4187769 Replicon chromosome
Accession NZ_CP110339
Organism Brucella sp. JSBI001

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LJ361_RS20010 Protein ID WP_264812156.1
Coordinates 4187096..4187518 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LJ361_RS20015 Protein ID WP_264813611.1
Coordinates 4187515..4187769 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJ361_RS19965 (LJ361_19965) 4182236..4182505 - 270 WP_264812146.1 helix-turn-helix domain-containing protein -
LJ361_RS19970 (LJ361_19970) 4182996..4183283 + 288 WP_264812147.1 DUF2285 domain-containing protein -
LJ361_RS19975 (LJ361_19975) 4183356..4183670 + 315 WP_264812148.1 DUF6506 family protein -
LJ361_RS19980 (LJ361_19980) 4183728..4184249 - 522 WP_264813610.1 DUF2285 domain-containing protein -
LJ361_RS19985 (LJ361_19985) 4184296..4184511 - 216 WP_264812149.1 DUF6499 domain-containing protein -
LJ361_RS19990 (LJ361_19990) 4184637..4184819 - 183 WP_264812151.1 hypothetical protein -
LJ361_RS19995 (LJ361_19995) 4184822..4185661 - 840 WP_264812152.1 DUF932 domain-containing protein -
LJ361_RS20000 (LJ361_20000) 4186010..4186327 - 318 WP_264812153.1 DUF736 domain-containing protein -
LJ361_RS20005 (LJ361_20005) 4186603..4186857 + 255 WP_264812155.1 hypothetical protein -
LJ361_RS20010 (LJ361_20010) 4187096..4187518 - 423 WP_264812156.1 type II toxin-antitoxin system VapC family toxin Toxin
LJ361_RS20015 (LJ361_20015) 4187515..4187769 - 255 WP_264813611.1 plasmid stabilization protein Antitoxin
LJ361_RS20020 (LJ361_20020) 4187862..4188566 - 705 WP_264812158.1 hypothetical protein -
LJ361_RS20025 (LJ361_20025) 4188473..4188889 - 417 WP_264812161.1 hypothetical protein -
LJ361_RS20030 (LJ361_20030) 4189104..4191180 - 2077 Protein_3951 ParB/RepB/Spo0J family partition protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4159869..4202253 42384


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14851.90 Da        Isoelectric Point: 4.6556

>T263620 WP_264812156.1 NZ_CP110339:c4187518-4187096 [Brucella sp. JSBI001]
MILLDTNVVSEAMKPEQAPAVRDWLDEQAAETLYLSSVTVAELLFGIGAMPDGRRKQRLATTLDGLLPLFEGRILPFDTN
AARHYADLAVAARKAGKGFPTPDGYIAAIAADQGFAVATRDASAFNAAGVPVIDPWTAGH

Download         Length: 423 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9193.37 Da        Isoelectric Point: 7.3220

>AT263620 WP_264813611.1 NZ_CP110339:c4187769-4187515 [Brucella sp. JSBI001]
MPAVTIRNLSDETHRALKVRAAHHGRSTEAEMRDILEAAVRPTDRLRIGSALSALSREAGLTNADVEALEKGRDRTPATP
MSFE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References