Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2207474..2208105 Replicon chromosome
Accession NZ_CP110339
Organism Brucella sp. JSBI001

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LJ361_RS10435 Protein ID WP_151614776.1
Coordinates 2207474..2207875 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A256GGW7
Locus tag LJ361_RS10440 Protein ID WP_010660354.1
Coordinates 2207875..2208105 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJ361_RS10415 (LJ361_10415) 2202911..2204431 - 1521 WP_209418708.1 FAD-dependent oxidoreductase -
LJ361_RS10420 (LJ361_10420) 2204561..2205502 - 942 WP_226622753.1 LysR substrate-binding domain-containing protein -
LJ361_RS10425 (LJ361_10425) 2205627..2206787 - 1161 WP_029928521.1 mandelate racemase/muconate lactonizing enzyme family protein -
LJ361_RS10430 (LJ361_10430) 2206816..2207070 - 255 WP_029928523.1 hypothetical protein -
LJ361_RS10435 (LJ361_10435) 2207474..2207875 - 402 WP_151614776.1 tRNA(fMet)-specific endonuclease VapC Toxin
LJ361_RS10440 (LJ361_10440) 2207875..2208105 - 231 WP_010660354.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LJ361_RS10445 (LJ361_10445) 2208767..2209820 + 1054 Protein_2061 GSU2403 family nucleotidyltransferase fold protein -
LJ361_RS10450 (LJ361_10450) 2210194..2210730 + 537 WP_010660385.1 AAA family ATPase -
LJ361_RS10455 (LJ361_10455) 2211196..2211810 - 615 WP_010660386.1 cysteine hydrolase family protein -
LJ361_RS10460 (LJ361_10460) 2211837..2212886 + 1050 WP_235907984.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2193810..2226266 32456


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15000.06 Da        Isoelectric Point: 6.4799

>T263618 WP_151614776.1 NZ_CP110339:c2207875-2207474 [Brucella sp. JSBI001]
MLKYMLDTNICIFTIKNRPQQVREAFNRFHDQLCISSVSLMELIYGAEKSAHPEKNLAVVEGFAARLEVLSYDEPAANHT
GQLRAELARSGTPIGPYDQLIAGHARSRGLIIVTNNRTEFDRVPGLRVEDWTD

Download         Length: 402 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8487.53 Da        Isoelectric Point: 4.5045

>AT263618 WP_010660354.1 NZ_CP110339:c2208105-2207875 [Brucella sp. JSBI001]
MEQGAVFQSNRSQAIRLPKAVALPADVKRVDIVAVGRTRIIAPAGEVWDSWFDSLEATSDFMNERDQPAPQEREAF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A256GGW7

References