Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2193613..2194187 Replicon chromosome
Accession NZ_CP110339
Organism Brucella sp. JSBI001

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LJ361_RS10370 Protein ID WP_151576612.1
Coordinates 2193810..2194187 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A849KU45
Locus tag LJ361_RS10365 Protein ID WP_010660355.1
Coordinates 2193613..2193813 (+) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJ361_RS10350 (LJ361_10350) 2189233..2189826 - 594 WP_010660339.1 biliverdin-producing heme oxygenase -
LJ361_RS10355 (LJ361_10355) 2189877..2190605 - 729 WP_010660340.1 Crp/Fnr family transcriptional regulator -
LJ361_RS10360 (LJ361_10360) 2190868..2193402 + 2535 WP_010660341.1 HWE histidine kinase domain-containing protein -
LJ361_RS10365 (LJ361_10365) 2193613..2193813 + 201 WP_010660355.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LJ361_RS10370 (LJ361_10370) 2193810..2194187 + 378 WP_151576612.1 type II toxin-antitoxin system VapC family toxin Toxin
LJ361_RS10375 (LJ361_10375) 2194441..2195370 - 930 WP_151614781.1 LysR family transcriptional regulator -
LJ361_RS10380 (LJ361_10380) 2195481..2196185 + 705 WP_151607228.1 HAD-IA family hydrolase -
LJ361_RS10385 (LJ361_10385) 2196214..2197509 + 1296 WP_209418706.1 FAD-binding oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-110)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13988.20 Da        Isoelectric Point: 7.0615

>T263617 WP_151576612.1 NZ_CP110339:2193810-2194187 [Brucella sp. JSBI001]
VILADTSIWIDHFRRGDNDLVKIIGNDLLLCHPAVIGELALGSLRDRTAVLTFLRAQRETIVATHDEVMTLIERHSVFSM
GIGYTDAHLLASVLLDQRTSLWTRDKRLKLAALKAGAALYEPFHN

Download         Length: 378 bp

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7162.26 Da        Isoelectric Point: 11.1107

>AT263617 WP_010660355.1 NZ_CP110339:2193613-2193813 [Brucella sp. JSBI001]
MRSTINLDDNLLEKARSLTGTKETAALVRQALEALVRVETGKRLIALGGTMPDAEAAPRRRSSVNK

Download         Length: 201 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A849KU45

References