Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 50615..51282 Replicon plasmid pA
Accession NZ_CP110316
Organism Xanthomonas phaseoli pv. phaseoli strain UnB187

Toxin (Protein)


Gene name vapC Uniprot ID A0A3T0G501
Locus tag OM951_RS22710 Protein ID WP_022557732.1
Coordinates 50615..51031 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U4M4Z6
Locus tag OM951_RS22715 Protein ID WP_022557731.1
Coordinates 51028..51282 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM951_RS22685 (OM951_22685) 46345..47664 + 1320 WP_022557736.1 right-handed parallel beta-helix repeat-containing protein -
OM951_RS22690 (OM951_22690) 47791..49083 + 1293 WP_041019649.1 M12 family metallo-peptidase -
OM951_RS22695 (OM951_22695) 49238..49786 + 549 WP_022557734.1 DNA topoisomerase -
OM951_RS22700 (OM951_22700) 49835..49972 + 138 Protein_61 transposase -
OM951_RS22705 (OM951_22705) 50047..50601 - 555 WP_033482006.1 plasmid pRiA4b ORF-3 family protein -
OM951_RS22710 (OM951_22710) 50615..51031 - 417 WP_022557732.1 type II toxin-antitoxin system VapC family toxin Toxin
OM951_RS22715 (OM951_22715) 51028..51282 - 255 WP_022557731.1 plasmid stability protein Antitoxin
OM951_RS22720 (OM951_22720) 51494..52087 + 594 WP_022560487.1 recombinase family protein -
OM951_RS22725 (OM951_22725) 52084..55113 + 3030 WP_022560486.1 Tn3 family transposase -
OM951_RS22730 (OM951_22730) 55146..55531 + 386 Protein_67 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - virB1 1..57743 57743
- inside IScluster/Tn - - 49835..56687 6852


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14833.04 Da        Isoelectric Point: 4.6812

>T263613 WP_022557732.1 NZ_CP110316:c51031-50615 [Xanthomonas phaseoli pv. phaseoli]
MIVLDTNVVSEAMKPEPHPSVRTWLNDQAAETLYLSSVTLAELLFGIAALPAGKRKDMLEQALDGLMGLFRDRVLPFDID
AARRYAELAVTAKIGGRGFPTPDGYIAAIAASRGFIVASRDTAPYEAAGVTVINPWEG

Download         Length: 417 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9388.80 Da        Isoelectric Point: 8.9326

>AT263613 WP_022557731.1 NZ_CP110316:c51282-51028 [Xanthomonas phaseoli pv. phaseoli]
MAMLTVRNLPDDVHRALRMRAAQNGHSTEAEVREILATAVKPETRVRLGEALAALGRKIGLTNEDFEVFDRVRDKTPAVP
PRLE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0G501

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0G545

References