Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 48106..48773 Replicon plasmid pA
Accession NZ_CP110314
Organism Xanthomonas phaseoli pv. phaseoli strain BB007a

Toxin (Protein)


Gene name vapC Uniprot ID A0A3T0G501
Locus tag OM954_RS22930 Protein ID WP_022557732.1
Coordinates 48106..48522 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U4M4Z6
Locus tag OM954_RS22935 Protein ID WP_022557731.1
Coordinates 48519..48773 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM954_RS22905 (OM954_22905) 43836..45155 + 1320 WP_022557736.1 right-handed parallel beta-helix repeat-containing protein -
OM954_RS22910 (OM954_22910) 45282..46574 + 1293 WP_033481893.1 M12 family metallo-peptidase -
OM954_RS22915 (OM954_22915) 46729..47277 + 549 WP_022557734.1 DNA topoisomerase -
OM954_RS22920 (OM954_22920) 47326..47463 + 138 Protein_57 transposase -
OM954_RS22925 (OM954_22925) 47538..48092 - 555 WP_033482006.1 plasmid pRiA4b ORF-3 family protein -
OM954_RS22930 (OM954_22930) 48106..48522 - 417 WP_022557732.1 type II toxin-antitoxin system VapC family toxin Toxin
OM954_RS22935 (OM954_22935) 48519..48773 - 255 WP_022557731.1 plasmid stability protein Antitoxin
OM954_RS22940 (OM954_22940) 48985..49578 + 594 WP_022560487.1 recombinase family protein -
OM954_RS22945 (OM954_22945) 49575..52604 + 3030 WP_022560486.1 Tn3 family transposase -
OM954_RS22950 (OM954_22950) 52637..53022 + 386 Protein_63 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - virB1 1..58786 58786
- inside IScluster/Tn - virB1 47326..58711 11385


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14833.04 Da        Isoelectric Point: 4.6812

>T263610 WP_022557732.1 NZ_CP110314:c48522-48106 [Xanthomonas phaseoli pv. phaseoli]
MIVLDTNVVSEAMKPEPHPSVRTWLNDQAAETLYLSSVTLAELLFGIAALPAGKRKDMLEQALDGLMGLFRDRVLPFDID
AARRYAELAVTAKIGGRGFPTPDGYIAAIAASRGFIVASRDTAPYEAAGVTVINPWEG

Download         Length: 417 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9388.80 Da        Isoelectric Point: 8.9326

>AT263610 WP_022557731.1 NZ_CP110314:c48773-48519 [Xanthomonas phaseoli pv. phaseoli]
MAMLTVRNLPDDVHRALRMRAAQNGHSTEAEVREILATAVKPETRVRLGEALAALGRKIGLTNEDFEVFDRVRDKTPAVP
PRLE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0G501

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0G545

References