Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 40099..40766 Replicon plasmid pA
Accession NZ_CP110300
Organism Xanthomonas citri pv. fuscans strain BRM48906

Toxin (Protein)


Gene name vapC Uniprot ID A0A3T0G501
Locus tag OM948_RS22455 Protein ID WP_022557732.1
Coordinates 40350..40766 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U4M4Z6
Locus tag OM948_RS22450 Protein ID WP_022557731.1
Coordinates 40099..40353 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM948_RS22435 (OM948_22435) 35277..36235 - 959 Protein_36 IS3-like element ISXcd1 family transposase -
OM948_RS22440 (OM948_22440) 36268..39297 - 3030 WP_022560486.1 Tn3 family transposase -
OM948_RS22445 (OM948_22445) 39294..39887 - 594 WP_022560487.1 recombinase family protein -
OM948_RS22450 (OM948_22450) 40099..40353 + 255 WP_022557731.1 plasmid stability protein Antitoxin
OM948_RS22455 (OM948_22455) 40350..40766 + 417 WP_022557732.1 type II toxin-antitoxin system VapC family toxin Toxin
OM948_RS22460 (OM948_22460) 40780..41334 + 555 WP_033482006.1 plasmid pRiA4b ORF-3 family protein -
OM948_RS22465 (OM948_22465) 41409..41546 - 138 Protein_42 transposase -
OM948_RS22470 (OM948_22470) 41595..42143 - 549 WP_022557734.1 DNA topoisomerase -
OM948_RS22475 (OM948_22475) 42298..43590 - 1293 WP_033481893.1 M12 family metallo-peptidase -
OM948_RS22480 (OM948_22480) 43717..45036 - 1320 WP_022557736.1 right-handed parallel beta-helix repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..57068 57068
- inside IScluster/Tn - - 35277..41546 6269


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14833.04 Da        Isoelectric Point: 4.6812

>T263592 WP_022557732.1 NZ_CP110300:40350-40766 [Xanthomonas citri pv. fuscans]
MIVLDTNVVSEAMKPEPHPSVRTWLNDQAAETLYLSSVTLAELLFGIAALPAGKRKDMLEQALDGLMGLFRDRVLPFDID
AARRYAELAVTAKIGGRGFPTPDGYIAAIAASRGFIVASRDTAPYEAAGVTVINPWEG

Download         Length: 417 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9388.80 Da        Isoelectric Point: 8.9326

>AT263592 WP_022557731.1 NZ_CP110300:40099-40353 [Xanthomonas citri pv. fuscans]
MAMLTVRNLPDDVHRALRMRAAQNGHSTEAEVREILATAVKPETRVRLGEALAALGRKIGLTNEDFEVFDRVRDKTPAVP
PRLE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0G501

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0G545

References