Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 215964..216493 Replicon chromosome
Accession NZ_CP110294
Organism Enterococcus faecium strain AKSZ-47

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag MZO30_RS02210 Protein ID WP_002294198.1
Coordinates 216227..216493 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag MZO30_RS02205 Protein ID WP_002294199.1
Coordinates 215964..216227 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MZO30_RS02190 (MZO30_02190) 213339..215162 + 1824 WP_002294202.1 APC family permease -
MZO30_RS02195 (MZO30_02195) 215304..215489 - 186 WP_002294201.1 hypothetical protein -
MZO30_RS02200 (MZO30_02200) 215496..215624 + 129 WP_002294200.1 hypothetical protein -
MZO30_RS02205 (MZO30_02205) 215964..216227 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MZO30_RS02210 (MZO30_02210) 216227..216493 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
MZO30_RS02215 (MZO30_02215) 216694..217182 + 489 WP_002294196.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
MZO30_RS02220 (MZO30_02220) 217245..217412 + 168 WP_002294195.1 hypothetical protein -
MZO30_RS02225 (MZO30_02225) 217724..218377 - 654 WP_002317081.1 ABC transporter permease -
MZO30_RS02230 (MZO30_02230) 218392..219309 - 918 WP_002294193.1 osmoprotectant ABC transporter substrate-binding protein -
MZO30_RS02235 (MZO30_02235) 219306..219947 - 642 WP_002293405.1 ABC transporter permease -
MZO30_RS02240 (MZO30_02240) 219951..221126 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T263583 WP_002294198.1 NZ_CP110294:216227-216493 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT263583 WP_002294199.1 NZ_CP110294:215964-216227 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References