Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2723955..2724526 Replicon chromosome
Accession NZ_CP110289
Organism Enterococcus faecalis strain AKSZ-208

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MZO28_RS13505 Protein ID WP_002354774.1
Coordinates 2723955..2724296 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag MZO28_RS13510 Protein ID WP_002354773.1
Coordinates 2724296..2724526 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MZO28_RS13500 (2719970) 2719970..2723584 - 3615 WP_265453594.1 DNA-directed RNA polymerase subunit beta -
MZO28_RS13505 (2723955) 2723955..2724296 - 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MZO28_RS13510 (2724296) 2724296..2724526 - 231 WP_002354773.1 hypothetical protein Antitoxin
MZO28_RS13515 (2724857) 2724857..2725072 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
MZO28_RS13520 (2725211) 2725211..2726203 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
MZO28_RS13525 (2726467) 2726467..2727105 - 639 WP_073438309.1 lytic polysaccharide monooxygenase -
MZO28_RS13530 (2727791) 2727791..2729407 + 1617 WP_002406969.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T263570 WP_002354774.1 NZ_CP110289:c2724296-2723955 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT263570 WP_002354773.1 NZ_CP110289:c2724526-2724296 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References