Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 414121..414703 Replicon chromosome
Accession NZ_CP110289
Organism Enterococcus faecalis strain AKSZ-208

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag MZO28_RS02475 Protein ID WP_002355414.1
Coordinates 414395..414703 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag MZO28_RS02470 Protein ID WP_002326825.1
Coordinates 414121..414393 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MZO28_RS02450 (409802) 409802..411478 + 1677 WP_010709001.1 type IA DNA topoisomerase -
MZO28_RS02460 (412964) 412964..413818 + 855 WP_015212161.1 ParA family protein -
MZO28_RS02465 (413889) 413889..414104 + 216 WP_002355411.1 peptide-binding protein -
MZO28_RS02470 (414121) 414121..414393 + 273 WP_002326825.1 antitoxin Antitoxin
MZO28_RS02475 (414395) 414395..414703 + 309 WP_002355414.1 zeta toxin family protein Toxin
MZO28_RS02480 (414783) 414783..415205 - 423 WP_080005963.1 tyrosine-type recombinase/integrase -
MZO28_RS02485 (415256) 415256..415756 - 501 WP_002355415.1 HAD family hydrolase -
MZO28_RS02490 (415761) 415761..416528 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
MZO28_RS02495 (417017) 417017..417442 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
MZO28_RS02500 (417459) 417459..417974 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
MZO28_RS02505 (417985) 417985..418917 + 933 WP_002363040.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T263559 WP_002355414.1 NZ_CP110289:414395-414703 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT263559 WP_002326825.1 NZ_CP110289:414121-414393 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References