Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 3490053..3491028 Replicon chromosome
Accession NZ_CP110287
Organism Bacillus anthracis strain DP-B-5747

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag OM983_RS18280 Protein ID WP_002036394.1
Coordinates 3490053..3490790 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag OM983_RS18285 Protein ID WP_000588712.1
Coordinates 3490903..3491028 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM983_RS18260 (OM983_18260) 3485781..3486563 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
OM983_RS18265 (OM983_18265) 3486685..3488370 - 1686 WP_009879073.1 alpha-keto acid decarboxylase family protein -
OM983_RS18270 (OM983_18270) 3488477..3488959 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
OM983_RS18275 (OM983_18275) 3489127..3489864 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
OM983_RS18280 (OM983_18280) 3490053..3490790 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
OM983_RS18285 (OM983_18285) 3490903..3491028 + 126 WP_000588712.1 hypothetical protein Antitoxin
OM983_RS18290 (OM983_18290) 3491105..3491281 + 177 WP_000852614.1 hypothetical protein -
OM983_RS18295 (OM983_18295) 3491318..3491599 - 282 WP_001041555.1 hypothetical protein -
OM983_RS18300 (OM983_18300) 3491876..3492112 - 237 WP_001021689.1 hypothetical protein -
OM983_RS18305 (OM983_18305) 3492249..3492374 + 126 WP_000694311.1 hypothetical protein -
OM983_RS18310 (OM983_18310) 3492451..3492627 + 177 WP_000808045.1 stage II sporulation protein SB -
OM983_RS18315 (OM983_18315) 3492771..3494240 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
OM983_RS18320 (OM983_18320) 3494804..3495274 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T263558 WP_002036394.1 NZ_CP110287:3490053-3490790 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT263558 WP_000588712.1 NZ_CP110287:3490903-3491028 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References