Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 1414664..1415306 Replicon chromosome
Accession NZ_CP110287
Organism Bacillus anthracis strain DP-B-5747

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag OM983_RS07510 Protein ID WP_000635963.1
Coordinates 1414956..1415306 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag OM983_RS07505 Protein ID WP_000004570.1
Coordinates 1414664..1414951 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM983_RS07480 (OM983_07480) 1409980..1410942 + 963 WP_000961037.1 UV DNA damage repair endonuclease UvsE -
OM983_RS07485 (OM983_07485) 1410935..1411507 - 573 WP_000906916.1 rhomboid family intramembrane serine protease -
OM983_RS07490 (OM983_07490) 1411600..1411959 + 360 WP_000635040.1 holo-ACP synthase -
OM983_RS07495 (OM983_07495) 1412116..1413066 + 951 WP_025388382.1 outer membrane lipoprotein carrier protein LolA -
OM983_RS07500 (OM983_07500) 1413185..1414354 + 1170 WP_000390596.1 alanine racemase -
OM983_RS07505 (OM983_07505) 1414664..1414951 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
OM983_RS07510 (OM983_07510) 1414956..1415306 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
OM983_RS07515 (OM983_07515) 1415374..1417542 + 2169 WP_000426225.1 Tex family protein -
OM983_RS07520 (OM983_07520) 1417600..1417716 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
OM983_RS07525 (OM983_07525) 1417912..1418370 + 459 WP_000344248.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T263557 WP_000635963.1 NZ_CP110287:1414956-1415306 [Bacillus anthracis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT263557 WP_000004570.1 NZ_CP110287:1414664-1414951 [Bacillus anthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References