Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2314660..2315635 Replicon chromosome
Accession NZ_CP110285
Organism Bacillus anthracis strain BA755

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag OM980_RS12060 Protein ID WP_002036394.1
Coordinates 2314660..2315397 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag OM980_RS12065 Protein ID WP_000588712.1
Coordinates 2315510..2315635 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM980_RS12040 (OM980_12040) 2310388..2311170 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
OM980_RS12045 (OM980_12045) 2311292..2312977 - 1686 WP_009879073.1 alpha-keto acid decarboxylase family protein -
OM980_RS12050 (OM980_12050) 2313084..2313566 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
OM980_RS12055 (OM980_12055) 2313734..2314471 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
OM980_RS12060 (OM980_12060) 2314660..2315397 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
OM980_RS12065 (OM980_12065) 2315510..2315635 + 126 WP_000588712.1 hypothetical protein Antitoxin
OM980_RS12070 (OM980_12070) 2315712..2315888 + 177 WP_000852614.1 hypothetical protein -
OM980_RS12075 (OM980_12075) 2315925..2316206 - 282 WP_001041555.1 hypothetical protein -
OM980_RS12080 (OM980_12080) 2316483..2316719 - 237 WP_001021689.1 hypothetical protein -
OM980_RS12085 (OM980_12085) 2316856..2316981 + 126 WP_000694311.1 hypothetical protein -
OM980_RS12090 (OM980_12090) 2317377..2318846 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
OM980_RS12095 (OM980_12095) 2319410..2319880 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T263556 WP_002036394.1 NZ_CP110285:2314660-2315397 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT263556 WP_000588712.1 NZ_CP110285:2315510-2315635 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References