Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 240356..240998 Replicon chromosome
Accession NZ_CP110285
Organism Bacillus anthracis strain BA755

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag OM980_RS01305 Protein ID WP_000635963.1
Coordinates 240648..240998 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag OM980_RS01300 Protein ID WP_000004570.1
Coordinates 240356..240643 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM980_RS01275 (OM980_01275) 235672..236634 + 963 WP_000961037.1 UV DNA damage repair endonuclease UvsE -
OM980_RS01280 (OM980_01280) 236627..237199 - 573 WP_000906916.1 rhomboid family intramembrane serine protease -
OM980_RS01285 (OM980_01285) 237292..237651 + 360 WP_000635040.1 holo-ACP synthase -
OM980_RS01290 (OM980_01290) 237808..238758 + 951 WP_025388382.1 outer membrane lipoprotein carrier protein LolA -
OM980_RS01295 (OM980_01295) 238877..240046 + 1170 WP_000390596.1 alanine racemase -
OM980_RS01300 (OM980_01300) 240356..240643 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
OM980_RS01305 (OM980_01305) 240648..240998 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
OM980_RS01310 (OM980_01310) 241066..243234 + 2169 WP_000426225.1 Tex family protein -
OM980_RS01315 (OM980_01315) 243292..243408 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
OM980_RS01320 (OM980_01320) 243604..244062 + 459 WP_000344248.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T263555 WP_000635963.1 NZ_CP110285:240648-240998 [Bacillus anthracis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT263555 WP_000004570.1 NZ_CP110285:240356-240643 [Bacillus anthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References