263553

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 240342..240984 Replicon chromosome
Accession NZ_CP110283
Organism Bacillus anthracis strain BA754

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag OM985_RS01305 Protein ID WP_000635963.1
Coordinates 240634..240984 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag OM985_RS01300 Protein ID WP_000004570.1
Coordinates 240342..240629 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM985_RS01275 (OM985_01275) 235658..236620 + 963 WP_000961037.1 UV DNA damage repair endonuclease UvsE -
OM985_RS01280 (OM985_01280) 236613..237185 - 573 WP_000906916.1 rhomboid family intramembrane serine protease -
OM985_RS01285 (OM985_01285) 237278..237637 + 360 WP_000635040.1 holo-ACP synthase -
OM985_RS01290 (OM985_01290) 237794..238744 + 951 WP_025388382.1 outer membrane lipoprotein carrier protein LolA -
OM985_RS01295 (OM985_01295) 238863..240032 + 1170 WP_000390596.1 alanine racemase -
OM985_RS01300 (OM985_01300) 240342..240629 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
OM985_RS01305 (OM985_01305) 240634..240984 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
OM985_RS01310 (OM985_01310) 241052..243220 + 2169 WP_000426225.1 Tex family protein -
OM985_RS01315 (OM985_01315) 243278..243394 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
OM985_RS01320 (OM985_01320) 243590..244048 + 459 WP_000344248.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T263553 WP_000635963.1 NZ_CP110283:240634-240984 [Bacillus anthracis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT263553 WP_000004570.1 NZ_CP110283:240342-240629 [Bacillus anthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References