263551

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 579095..580070 Replicon chromosome
Accession NZ_CP110281
Organism Bacillus anthracis strain BA749

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag OM981_RS03000 Protein ID WP_002036394.1
Coordinates 579095..579832 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag OM981_RS03005 Protein ID WP_000588712.1
Coordinates 579945..580070 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM981_RS02980 (OM981_02980) 574823..575605 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
OM981_RS02985 (OM981_02985) 575727..577412 - 1686 WP_009879073.1 alpha-keto acid decarboxylase family protein -
OM981_RS02990 (OM981_02990) 577519..578001 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
OM981_RS02995 (OM981_02995) 578169..578906 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
OM981_RS03000 (OM981_03000) 579095..579832 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
OM981_RS03005 (OM981_03005) 579945..580070 + 126 WP_000588712.1 hypothetical protein Antitoxin
OM981_RS03010 (OM981_03010) 580147..580323 + 177 WP_000852614.1 hypothetical protein -
OM981_RS03015 (OM981_03015) 580360..580641 - 282 WP_001041555.1 hypothetical protein -
OM981_RS03020 (OM981_03020) 580918..581154 - 237 WP_001021689.1 hypothetical protein -
OM981_RS03025 (OM981_03025) 581291..581416 + 126 WP_000694311.1 hypothetical protein -
OM981_RS03030 (OM981_03030) 581493..581669 + 177 WP_000808045.1 stage II sporulation protein SB -
OM981_RS03035 (OM981_03035) 581813..583282 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
OM981_RS03040 (OM981_03040) 583846..584316 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T263551 WP_002036394.1 NZ_CP110281:579095-579832 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT263551 WP_000588712.1 NZ_CP110281:579945-580070 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References