Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 4497453..4498428 Replicon chromosome
Accession NZ_CP110279
Organism Bacillus anthracis strain 7702

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag OM984_RS23675 Protein ID WP_002036394.1
Coordinates 4497453..4498190 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag OM984_RS23680 Protein ID WP_139870998.1
Coordinates 4498303..4498428 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM984_RS23655 (OM984_23655) 4493181..4493963 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
OM984_RS23660 (OM984_23660) 4494085..4495770 - 1686 WP_009879073.1 alpha-keto acid decarboxylase family protein -
OM984_RS23665 (OM984_23665) 4495877..4496359 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
OM984_RS23670 (OM984_23670) 4496527..4497264 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
OM984_RS23675 (OM984_23675) 4497453..4498190 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
OM984_RS23680 (OM984_23680) 4498303..4498428 + 126 WP_139870998.1 D-alanyl-D-alanine carboxypeptidase Antitoxin
OM984_RS23685 (OM984_23685) 4498505..4498681 + 177 WP_000852614.1 hypothetical protein -
OM984_RS23690 (OM984_23690) 4498718..4498903 - 186 WP_002036392.1 hypothetical protein -
OM984_RS23695 (OM984_23695) 4499275..4499511 - 237 WP_001021689.1 hypothetical protein -
OM984_RS23700 (OM984_23700) 4499648..4499773 + 126 WP_000694311.1 hypothetical protein -
OM984_RS23705 (OM984_23705) 4499850..4500026 + 177 WP_000808045.1 stage II sporulation protein SB -
OM984_RS23710 (OM984_23710) 4500170..4501639 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
OM984_RS23715 (OM984_23715) 4502203..4502673 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T263550 WP_002036394.1 NZ_CP110279:4497453-4498190 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4956.38 Da        Isoelectric Point: 3.9150

>AT263550 WP_139870998.1 NZ_CP110279:4498303-4498428 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTMQQVEELEEELKRK

Download         Length: 126 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure

References