Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 2422181..2422823 Replicon chromosome
Accession NZ_CP110279
Organism Bacillus anthracis strain 7702

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag OM984_RS12900 Protein ID WP_000635963.1
Coordinates 2422473..2422823 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag OM984_RS12895 Protein ID WP_000004570.1
Coordinates 2422181..2422468 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OM984_RS12870 (OM984_12870) 2417497..2418459 + 963 WP_000961037.1 UV DNA damage repair endonuclease UvsE -
OM984_RS12875 (OM984_12875) 2418452..2419024 - 573 WP_000906916.1 rhomboid family intramembrane serine protease -
OM984_RS12880 (OM984_12880) 2419117..2419476 + 360 WP_000635040.1 holo-ACP synthase -
OM984_RS12885 (OM984_12885) 2419633..2420583 + 951 WP_025388382.1 outer membrane lipoprotein carrier protein LolA -
OM984_RS12890 (OM984_12890) 2420702..2421871 + 1170 WP_000390596.1 alanine racemase -
OM984_RS12895 (OM984_12895) 2422181..2422468 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
OM984_RS12900 (OM984_12900) 2422473..2422823 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
OM984_RS12905 (OM984_12905) 2422891..2425059 + 2169 WP_000426225.1 Tex family protein -
OM984_RS12910 (OM984_12910) 2425117..2425233 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
OM984_RS12915 (OM984_12915) 2425429..2425887 + 459 WP_000344248.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T263549 WP_000635963.1 NZ_CP110279:2422473-2422823 [Bacillus anthracis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT263549 WP_000004570.1 NZ_CP110279:2422181-2422468 [Bacillus anthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References