Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 857588..858245 Replicon chromosome
Accession NZ_CP110265
Organism Klebsiella pneumoniae strain YZ22CS070

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OMD39_RS04280 Protein ID WP_002916310.1
Coordinates 857835..858245 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OMD39_RS04275 Protein ID WP_002916312.1
Coordinates 857588..857854 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD39_RS04250 (852744) 852744..854177 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
OMD39_RS04255 (854296) 854296..855024 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OMD39_RS04260 (855074) 855074..855385 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
OMD39_RS04265 (855549) 855549..856208 + 660 WP_002916317.1 hemolysin III family protein -
OMD39_RS04270 (856359) 856359..857342 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
OMD39_RS04275 (857588) 857588..857854 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OMD39_RS04280 (857835) 857835..858245 + 411 WP_002916310.1 protein YgfX Toxin
OMD39_RS04285 (858252) 858252..858773 - 522 WP_002916308.1 flavodoxin FldB -
OMD39_RS04290 (858874) 858874..859770 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OMD39_RS04295 (859793) 859793..860506 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OMD39_RS04300 (860512) 860512..862245 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T263528 WP_002916310.1 NZ_CP110265:857835-858245 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT263528 WP_002916312.1 NZ_CP110265:857588-857854 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References