263524

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1425126..1426042 Replicon chromosome
Accession NZ_CP110264
Organism Bacillus halotolerans strain HMB20199

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A7G7U9Y2
Locus tag OMK57_RS07280 Protein ID WP_024121091.1
Coordinates 1425296..1426042 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A7G7U9Y3
Locus tag OMK57_RS07275 Protein ID WP_024121090.1
Coordinates 1425126..1425296 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMK57_RS07235 (OMK57_07235) 1420495..1420767 + 273 WP_044156234.1 hypothetical protein -
OMK57_RS07240 (OMK57_07240) 1420770..1422737 + 1968 WP_069486429.1 pyocin knob domain-containing protein -
OMK57_RS07245 (OMK57_07245) 1422751..1423140 + 390 WP_059336104.1 hypothetical protein -
OMK57_RS07250 (OMK57_07250) 1423182..1423280 + 99 WP_264798417.1 XkdX family protein -
OMK57_RS07255 (OMK57_07255) 1423409..1423687 + 279 WP_059336102.1 hemolysin XhlA family protein -
OMK57_RS07260 (OMK57_07260) 1423699..1423962 + 264 WP_024121086.1 phage holin -
OMK57_RS07265 (OMK57_07265) 1423975..1424868 + 894 WP_059336101.1 N-acetylmuramoyl-L-alanine amidase -
OMK57_RS07270 (OMK57_07270) 1424905..1425042 - 138 WP_125825426.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
OMK57_RS07275 (OMK57_07275) 1425126..1425296 - 171 WP_024121090.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
OMK57_RS07280 (OMK57_07280) 1425296..1426042 - 747 WP_024121091.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
OMK57_RS07285 (OMK57_07285) 1426151..1427152 - 1002 WP_044156221.1 inorganic phosphate transporter -
OMK57_RS07290 (OMK57_07290) 1427165..1427782 - 618 WP_044156219.1 DUF47 domain-containing protein -
OMK57_RS07295 (OMK57_07295) 1428060..1429376 - 1317 WP_059336100.1 serine/threonine exchanger -
OMK57_RS07300 (OMK57_07300) 1429771..1430721 + 951 WP_069486430.1 ring-cleaving dioxygenase -
OMK57_RS07305 (OMK57_07305) 1430887..1430967 + 81 Protein_1376 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29076.48 Da        Isoelectric Point: 4.4986

>T263524 WP_024121091.1 NZ_CP110264:c1426042-1425296 [Bacillus halotolerans]
MLLFFQIMVWCTMAALGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMIYWTYDPSSLFTNWERYVIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLDRLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMNLTASL
CHYSTQSDKDRLTEHMEDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQSYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6578.62 Da        Isoelectric Point: 10.9236

>AT263524 WP_024121090.1 NZ_CP110264:c1425296-1425126 [Bacillus halotolerans]
MENAFQNGCHPRAKKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G7U9Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A7G7U9Y3

References