Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 278405..279044 Replicon chromosome
Accession NZ_CP110263
Organism Peribacillus frigoritolerans strain HMB20428

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag OMJ04_RS01430 Protein ID WP_034306610.1
Coordinates 278694..279044 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag OMJ04_RS01425 Protein ID WP_034306380.1
Coordinates 278405..278686 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMJ04_RS01405 (OMJ04_01405) 274543..275133 - 591 WP_264896144.1 rhomboid family intramembrane serine protease -
OMJ04_RS01410 (OMJ04_01410) 275241..275591 + 351 WP_053537119.1 holo-ACP synthase -
OMJ04_RS01415 (OMJ04_01415) 275835..276839 + 1005 WP_053537120.1 outer membrane lipoprotein carrier protein LolA -
OMJ04_RS01420 (OMJ04_01420) 277057..278244 + 1188 WP_264897336.1 alanine racemase -
OMJ04_RS01425 (OMJ04_01425) 278405..278686 + 282 WP_034306380.1 antitoxin EndoAI Antitoxin
OMJ04_RS01430 (OMJ04_01430) 278694..279044 + 351 WP_034306610.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OMJ04_RS01435 (OMJ04_01435) 279460..280287 + 828 WP_054398282.1 RsbT co-antagonist protein RsbRA -
OMJ04_RS01440 (OMJ04_01440) 280290..280646 + 357 WP_048682053.1 STAS domain-containing protein -
OMJ04_RS01445 (OMJ04_01445) 280650..281051 + 402 WP_053537122.1 anti-sigma regulatory factor -
OMJ04_RS01450 (OMJ04_01450) 281061..282071 + 1011 WP_264896145.1 PP2C family protein-serine/threonine phosphatase -
OMJ04_RS01455 (OMJ04_01455) 282131..282463 + 333 WP_034306369.1 anti-sigma factor antagonist -
OMJ04_RS01460 (OMJ04_01460) 282460..282933 + 474 WP_053537124.1 anti-sigma B factor RsbW -
OMJ04_RS01465 (OMJ04_01465) 282911..283699 + 789 WP_034306363.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12955.06 Da        Isoelectric Point: 7.2029

>T263522 WP_034306610.1 NZ_CP110263:278694-279044 [Peribacillus frigoritolerans]
IVVKRGDVYFADLSPVVGSEQGGTRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEPMMQKVNEALQISLGLIEF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10713.13 Da        Isoelectric Point: 5.9054

>AT263522 WP_034306380.1 NZ_CP110263:278405-278686 [Peribacillus frigoritolerans]
VSESSATREILIRLPQNFLTELDGYASEENVNRSEFIYRATKMYLRERKKKEFRESMKRGYIEMAAINLTIASEAFQAEF
EAGHCVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References