Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 80780..81405 Replicon plasmid pKBSW16i-A
Accession NZ_CP110261
Organism Escherichia albertii strain KBSW16i

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N6N74_RS23485 Protein ID WP_000911333.1
Coordinates 81007..81405 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag N6N74_RS23480 Protein ID WP_000450520.1
Coordinates 80780..81007 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6N74_RS23480 (80780) 80780..81007 + 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
N6N74_RS23485 (81007) 81007..81405 + 399 WP_000911333.1 tRNA(fMet)-specific endonuclease VapC Toxin
N6N74_RS23490 (81414) 81414..81710 - 297 Protein_86 conjugal transfer protein TraD -
N6N74_RS23495 (81741) 81741..83312 - 1572 WP_000381395.1 IS66-like element ISCro1 family transposase -
N6N74_RS23500 (83332) 83332..83679 - 348 WP_000624622.1 IS66 family insertion sequence element accessory protein TnpB -
N6N74_RS23505 (83679) 83679..84356 - 678 WP_001339397.1 IS66-like element accessory protein TnpA -
N6N74_RS23510 (84409) 84409..86274 - 1866 Protein_90 type IV conjugative transfer system coupling protein TraD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(3'')-Ib / sitABCD vat / iutA / iucD / iucC / iucB / iucA 1..148447 148447


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14919.19 Da        Isoelectric Point: 7.8605

>T263516 WP_000911333.1 NZ_CP110261:81007-81405 [Escherichia albertii]
MLKFMLDTNICIFTMKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT263516 WP_000450520.1 NZ_CP110261:80780-81007 [Escherichia albertii]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References