Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3878302..3878953 Replicon chromosome
Accession NZ_CP110260
Organism Escherichia albertii strain KBSW16i

Toxin (Protein)


Gene name cptA Uniprot ID A0A8D9PM36
Locus tag N6N74_RS19105 Protein ID WP_044714929.1
Coordinates 3878549..3878953 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag N6N74_RS19100 Protein ID WP_000354046.1
Coordinates 3878302..3878568 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6N74_RS19070 (3873311) 3873311..3874204 + 894 WP_025238419.1 transporter -
N6N74_RS19075 (3874252) 3874252..3875685 - 1434 WP_059239141.1 6-phospho-beta-glucosidase BglA -
N6N74_RS19080 (3875730) 3875730..3876041 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
N6N74_RS19085 (3876209) 3876209..3876868 + 660 WP_000250281.1 hemolysin III family protein -
N6N74_RS19090 (3877070) 3877070..3878050 - 981 WP_059239129.1 tRNA-modifying protein YgfZ -
N6N74_RS19095 (3878082) 3878082..3878312 + 231 WP_000181267.1 hypothetical protein -
N6N74_RS19100 (3878302) 3878302..3878568 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
N6N74_RS19105 (3878549) 3878549..3878953 + 405 WP_044714929.1 protein YgfX Toxin
N6N74_RS19110 (3878992) 3878992..3879513 - 522 WP_044714926.1 flavodoxin FldB -
N6N74_RS19115 (3879625) 3879625..3880521 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
N6N74_RS19120 (3880546) 3880546..3881256 + 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N6N74_RS19125 (3881262) 3881262..3882995 + 1734 WP_059239127.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15835.76 Da        Isoelectric Point: 10.2082

>T263512 WP_044714929.1 NZ_CP110260:3878549-3878953 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLCLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT263512 WP_000354046.1 NZ_CP110260:3878302-3878568 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References