Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 2308418..2308994 Replicon chromosome
Accession NZ_CP110260
Organism Escherichia albertii strain KBSW16i

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag N6N74_RS11555 Protein ID WP_001297643.1
Coordinates 2308707..2308994 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag N6N74_RS11550 Protein ID WP_000063156.1
Coordinates 2308418..2308720 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6N74_RS11535 (2305014) 2305014..2307164 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
N6N74_RS11540 (2307214) 2307214..2307417 + 204 WP_000467859.1 YbdD/YjiX family protein -
N6N74_RS11545 (2307428) 2307428..2308384 + 957 WP_001297640.1 GTPase -
N6N74_RS11550 (2308418) 2308418..2308720 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
N6N74_RS11555 (2308707) 2308707..2308994 - 288 WP_001297643.1 BrnT family toxin Toxin
N6N74_RS11560 (2309193) 2309193..2309890 - 698 Protein_2259 IS1 family transposase -
N6N74_RS11565 (2309947) 2309947..2310042 + 96 Protein_2260 dienelactone hydrolase family protein -
N6N74_RS11570 (2310188) 2310188..2311420 + 1233 WP_262930122.1 multidrug efflux MFS transporter MdtM -
N6N74_RS11575 (2311461) 2311461..2312741 + 1281 WP_001037380.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2309193..2309402 209


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T263509 WP_001297643.1 NZ_CP110260:c2308994-2308707 [Escherichia albertii]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT263509 WP_000063156.1 NZ_CP110260:c2308720-2308418 [Escherichia albertii]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References