Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1595806..1596424 Replicon chromosome
Accession NZ_CP110260
Organism Escherichia albertii strain KBSW16i

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag N6N74_RS07985 Protein ID WP_001280991.1
Coordinates 1596206..1596424 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag N6N74_RS07980 Protein ID WP_000344798.1
Coordinates 1595806..1596180 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6N74_RS07970 (1590886) 1590886..1592079 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N6N74_RS07975 (1592102) 1592102..1595251 + 3150 WP_262930144.1 efflux RND transporter permease AcrB -
N6N74_RS07980 (1595806) 1595806..1596180 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
N6N74_RS07985 (1596206) 1596206..1596424 + 219 WP_001280991.1 HHA domain-containing protein Toxin
N6N74_RS07990 (1596601) 1596601..1597158 + 558 WP_025237467.1 maltose O-acetyltransferase -
N6N74_RS07995 (1597265) 1597265..1597735 + 471 WP_000136188.1 YlaC family protein -
N6N74_RS08000 (1597899) 1597899..1599449 + 1551 WP_001260378.1 EAL domain-containing protein -
N6N74_RS08005 (1599487) 1599487..1599840 - 354 WP_000878151.1 DUF1428 family protein -
N6N74_RS08015 (1600221) 1600221..1600532 + 312 WP_150003837.1 MGMT family protein -
N6N74_RS08020 (1600562) 1600562..1601134 - 573 WP_000779847.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T263507 WP_001280991.1 NZ_CP110260:1596206-1596424 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT263507 WP_000344798.1 NZ_CP110260:1595806-1596180 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References