Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 581593..582197 Replicon chromosome
Accession NZ_CP110260
Organism Escherichia albertii strain KBSW16i

Toxin (Protein)


Gene name doc Uniprot ID B1EM00
Locus tag N6N74_RS02915 Protein ID WP_000638401.1
Coordinates 581811..582197 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1ELZ9
Locus tag N6N74_RS02910 Protein ID WP_001195490.1
Coordinates 581593..581814 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6N74_RS02895 (577843) 577843..579294 + 1452 WP_044716705.1 tagaturonate reductase -
N6N74_RS02900 (579499) 579499..580413 + 915 WP_024164792.1 bestrophin family protein -
N6N74_RS02905 (580417) 580417..581175 - 759 WP_044709411.1 trans-aconitate 2-methyltransferase -
N6N74_RS02910 (581593) 581593..581814 + 222 WP_001195490.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N6N74_RS02915 (581811) 581811..582197 + 387 WP_000638401.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
N6N74_RS02920 (582277) 582277..583698 - 1422 WP_223274629.1 autotransporter outer membrane beta-barrel domain-containing protein -
N6N74_RS02925 (583691) 583691..587059 - 3369 WP_262929948.1 autotransporter-associated beta strand repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14505.49 Da        Isoelectric Point: 8.0833

>T263504 WP_000638401.1 NZ_CP110260:581811-582197 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLTDPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MTFLWRNGIRIRDVDNSLENLTVEAATGEKTVGQLARCLRERVDSSGN

Download         Length: 387 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8067.96 Da        Isoelectric Point: 4.6816

>AT263504 WP_001195490.1 NZ_CP110260:581593-581814 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T5VDW2

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6PD20

References